Rybelsus is a brand new oral medication for type 2 diabetes. Semaglutide is a general term for the same chemical that- was previously only available as a once-a-week injection called Ozempic.

Ozempic and Victoza (Liraglutide) are peptides- that are small proteins that are generally broken down_ in the gut and no longer work. It is Rybelsus engineering that allows it to be administered_ orally without fragmentation and still without effect.

The maximum dose of Ozempic injectable is 1 mg, and Rybelsus has a_ maximum dose of 14 mg. Different doses indicate that large amounts of Rybelsus are still broken- down in the intestines before ingestion.

Rybelsus comes in three different dosages;

3mg

7mg

14mg

In the first month, the initial dose of Rybelsus is 3 mg once daily (30 days). If the client can tolerate the drug after this period, the dose should be increased to 7 mg daily.

If your blood sugar remains high after 30 days on a 7 mg dose, your Rybelsus dose may be increased to 14 mg once daily. Two Rybelsus 7 mg tablets not_ should be taken to obtain a 14 mg dose to prevent confusion; Instead, the 14 mg tablet- should be taken alone.

Semaglutide is a synthetic form of a peptide similar to glucagon one (1) or GLP-1, a natural human hormone designed to be less likely to be broken down and have a longer duration of action.

GLP-1 is produced by everyone, whether they have diabetes or not. GLP-1 is an important hormone that helps regulate blood sugar levels_ as well as our appetite and weight.

Rybelsus is 94% identical to GLP-1 in humans. It can act in a similar way to natural GLP-1 in the body and therefore have very similar effects, for example:

When your blood sugar is high, your insulin secretion increases.

Less glucose is released- into the circulation from liver stores.

Decreased appetite.

GLP-1 is a hormone that everyone produces naturally. Rybelsus (Semaglutide) is a synthetic GLP-1 product_ that has 94% of the same structure as human GLP-1. The structure_ of semaglutide has been- changed to prevent it from being broken down by a blood enzyme called dipeptidyl peptidase-4 or DPP-4.

Rybelsus, like other GLP-1 drugs (Ozempic, Trulicity, Victoza, Bydureon, and Byetta), works by mimicking the body's natural hormone GLP-1 in response to rising blood sugar.

Ozempic is an injectable form of semaglutide and is an example of GLP-1 once a week. 

Rybelsus is given once daily and is the only oral tablet of GLP-1, whereas Ozempic is the injectable form of semaglutide and is an example of GLP-1 once a week.

 Truth is another example of the old working GLP-1 (generic name Dulaglutide).

DPP-4 inhibitors are drugs that block the function of DPP-4 and have long been used to treat type 2 diabetes. 

They increase the amount of GLP-1 in the body by small amounts by inhibiting the enzyme that breaks down natural GLP. -1. (Dipeptidyl peptidase-4 (DPP-4) inhibitors for the treatment_ of type 2 diabetes). 

DPP-4 inhibitors include the following:

sitagliptin (Januvia)

valdagliptin (Galvus)

saxagliptin (Onglyza)

linagliptin (Tradjenta)

alogliptin (Nesina)